Endocrine Abstracts

The purpose of the study: To examine the incidence of neuroendocrine complications after RT of pituitary somatotropinomas.Materials and methods: Thirty patients surveyed after receiving radiation therapy (RT) at a dose of 45 g in 25 fractions a day. Of these, 21 (70%) females, 9 (30%) men. The age of patients ranged from 36–71 years. 37% of them had pituitary macroadenoma with para-, supra-, infrasellar growth. Duration of illness was on average 15 ...

Purpose of the study: To determine the gender differences in growth hormone (GH) and insulin-like growth factor-1 (IGF-1) in patients with somatotropic pituitary adenomas after radiation therapy (RT).Materials and research methods: The object of the study is 94 patients with acromegaly receiving RT in a total dose of 45–50 gray. Of these, 26 (27.7%) are men and 68 (72.3%) are women. The peak manifestation of acromegaly in the total sample was in th...

The aim of the study was to study the incidence of osteo-articular complications in patients with acromegaly in the Ferghana Valley.Materials and methods: 129 patients with acromegaly in the Ferghana Valley who were included in the national register of acromegaly were examined. Of these, men – 46 (35.7%), women – 83 (64.3%). The average age of the patients was (48 ± 8.7 years). By age, patients were divided into three groups: 1 group &#8...

The aim: To define the prevalence pregnancy induced hypertension (eclampsia, severe preeclampsia, mild preeclampsia, and gestational hypertension) among women with gestational diabetes in Uzbek population.Material and Methods: The epidemiological study involved 1812 pregnant women from 6 pilot regions (Kashkadarya, Samarkand, Fergana, Surkhandarya, Namangan, Khorezm). GDM was screened for the first time among 1812 pregnant women in the period of 20&#8211...

Summary: Objective: To study the clinical manifestations of musculoskeletal complications (MSC) of acromegaly, to improve the early diagnosis of the disease.Materials and methods: 150 patients with acromegaly were examined who were observed at the RSSPMC of Endocrinology during the period from 2000 to 2020. The age of patients ranged from 19 to 76 years and averaged 43 ± 8.6 years. Of these, 65 (43.3%) were men and 85 (56.7%) women. Moreover, the du...

Aim of the research: To study diabetes insipidus (DI) prevalence in the Republic of Uzbekistan (RUZ) according to National Register.Materials and methods: Computerized database has developed which covers all 12 regions of RUZ and Republic of Karakalpakstan. Database includes 1822 patients with diabetes insipidus.Results: According to the register there are 1822 patients with DI which occurs in men and women with similar rate –...

Tashkent Pediatric Medical Institute, department of endocrinology, Center of the Scientific and Clinical Study of Endocrinology, department of neuroendocrinoloy, Ministry of Health of the Republic of Uzbekistan. Republic of Uzbekistan, 100125, Tashkent, Mirzo Ulugbek str. 56Z. Yu. Khalimova, G.D. Narimova, Yu.M. Urmanova, G/O/ Alimukhamedova. Sh.M. SafarovaThe aim: To study the characteristic of associated diseases in risk groups o...

Aim: The aim of investigation to study of the features of the Cushing’s subclinical syndrome in women (CS) with metabolic syndrome (MS)Material and methods: Under our supervision in the Department of neuroendocrinology of the Center of Endocrinology of MPH out-patient clinics with primary or secondary infertility in the period from September 2015 to July 2016 were examined 120 patients of childbearing age with metabolic syndrome in polycystic ovary ...

Aim: To study features of family inheritance in patients of non-functional pituitary adenomas (NFPA) in Uzbekistan.Materials and methods: We included 71 patients with NFPA, intrasellar localization (mean size >3 mm). Mean age was from 18 to 70 years old (range 44.5±3.85 years). Of 71 patients, 30 (42.3%) were men and 41 (57.7%) were women.All patients underwent clinical and biochemical evaluations including endocrine check...

Aim of the research: To study relationship between GH levels and acromegaly complications development in different therapy approaches.Patients and methods: We evaluated 50 patients with GH secreting adenomas referred to CCSSE from 1999 to 2004. Age of patients was from 19 to 63 years-old (mean age 40±19 years-old). Duration of the disease was from 1 to 23 years.Methods: Clinical and biochemical tests of neurological status; RI...